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Deciphering the Role of Environmental Exposures in Androgen-Resistant Prostate Cancer an Insights from Multi-Omics and Toxicogenomics
Abstract
Prostate cancer (PCa), especially androgen-resistant PCa (ARPC), poses a major global health burden shaped by both genetics and environmental exposures. This chapter examines how toxicants like endocrine disruptors, POPs, and xenobiotics contribute to PCa progression through exposomics, toxicogenomics, and multi-omics approaches. It highlights mechanisms such as AR signaling disruption, mitochondrial dysfunction, metabolic shifts, and epigenetic changes driving therapy resistance. Using cell models and spatial transcriptomics, it explores how exposures promote metastasis. The chapter also discusses tools like eDNA, epigenetic biomarkers, and predictive models for early detection and prevention, underscoring the importance of integrating environmental risk into precision oncology.
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