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Exposome Insights to Action A Unified Call for Cancer Prevention, and a Vision for Precision Prevention
Abstract
Cancer exposomics moves from data acquisition to actionable interventions through a multi-step, integrative approach that spans precise exposure assessment, mechanistic insight generation, and the translation the results into targeted prevention and treatment strategies. Comprehensive exposure assessment is performed by capturing external environmental factors and internal exposures using advanced tools which is accomplished by combining traditional methods with omic technologies, metabolomics, genomics, transcriptomics, and proteomics to elucidate the pathways by which environmental exposures modulate disease risk and progression. Cancer exposomics its ethical dimensions demand rigorous protections around consent, privacy, and responsible communication. This chapter explores the translational potential of exposomic science, emphasizing its ability to shape personalized cancer prevention strategies. It considers ethical, legal, and societal implications (ELSI), the role of public and community engagement, and culminates with a unified, multilevel call to action for cancer prevention.
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