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Polycystic Ovary Syndrome PCOS and Depression Role of Neuroinflammation
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Author(s): Mohammad Reza Ramezanpour (Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell, and Tissue Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran), Omid Bahrami (Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell, and Tissue Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran), Muhammad Parsa Pashazadeh (Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell, and Tissue Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran), Rojin Sarallah (Islamic Azad University Medical Branch of Tehran, Tehran, Iran), Reza Nikfar (Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell, and Tissue Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran)and Masoumeh Majidi Zolbin (Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran)
Copyright: 2026
Pages: 34
Source title:
Autophagy and Inflammation in Neuropsychological Disorders
Source Author(s)/Editor(s): Tahmineh Mokhtari (Hubei University of Medicine, China)and Kadir Uludag (Shanghai Jiao Tong University, China)
DOI: 10.4018/979-8-3693-5908-2.ch007
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Abstract
Polycystic ovary syndrome (PCOS) is a multidimensional condition with metabolic, hormonal, and neuropsychiatric effects. Depression is common among PCOS patients, and emerging research shows neuroinflammation as a probable reason. Chronic low-grade inflammation, insulin resistance, hyperandrogenism, and gut dysbiosis all contribute to neuroinflammatory processes, which result in hypothalamic dysfunction, neurotransmitter imbalances, and hypothalamic-pituitary-adrenal (HPA) axis dysregulation. Abnormal microglial activation and oxidative stress may further damage neuroplasticity, interfering with proper mood regulation. This chapter investigates how neuroinflammatory pathways influence the relationship between PCOS and depression, focusing on their effects on brain function and mood regulation. This chapter addresses neuroinflammation as a mechanism contributing to psychiatric symptoms in PCOS by identifying key inflammatory drivers, as well as prospective treatment targets.
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