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Autophagy Pathways in Major Depressive Disorder
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Author(s): Golnaz Shafiei (Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran), Maryam Saadat (Department of Anatomical Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran), Shima Farajpour (Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran), Shima Mohammadi (Department of Neuroscience, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran), Nasrin Dashti (Medical Laboratory Sciences, Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran)and Tahmineh Mokhtari (Department of Entomology and Nematology, University of California, Davis, USA)
Copyright: 2026
Pages: 38
Source title:
Autophagy and Inflammation in Neuropsychological Disorders
Source Author(s)/Editor(s): Tahmineh Mokhtari (Hubei University of Medicine, China)and Kadir Uludag (Shanghai Jiao Tong University, China)
DOI: 10.4018/979-8-3693-5908-2.ch004
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Abstract
Major depressive disorder (MDD) is a chronic condition with high prevalence, especially in individuals with physical illnesses. This chapter explores autophagy's involvement in MDD, connecting it to oxidative stress, increased pro-inflammatory cytokine levels, and impaired mitochondrial function. Dysregulated autophagy contributes to MDD pathophysiology, offering insights into novel therapeutic strategies. The authors review preclinical and clinical evidence, the effects of conventional antidepressants on autophagy, and the potential of herbal products in modulating these pathways. Understanding autophagy's role in MDD underscores the need for further research to develop targeted treatments.
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