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Autophagy in Spinal Cord Injury: A Double-Edged Sword in Preclinical Studies of Synthetic and Natural Compounds
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Author(s): Tahmineh Mokhtari (Department of Entomology and Nematology, University of California, Davis, USA), Farzaneh Majidi (Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran), Fatemeh Sheikhbahaei (Department of Anatomical Sciences, Kerman University of Medical Sciences, Kerman, Iran), Parvaneh Behi Shahreza (Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran)and Mahnaz Poorhassan (Department of Anatomical Sciences and Cognitive Neuroscience, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran)
Copyright: 2026
Pages: 36
Source title:
Autophagy and Inflammation in Neuropsychological Disorders
Source Author(s)/Editor(s): Tahmineh Mokhtari (Hubei University of Medicine, China)and Kadir Uludag (Shanghai Jiao Tong University, China)
DOI: 10.4018/979-8-3693-5908-2.ch005
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Abstract
Autophagy is a crucial cellular process involved in spinal cord injury (SCI) pathophysiology. It can protect neural tissues by removing damaged cellular components, thereby promoting recovery. However, excessive autophagy may lead to neuronal apoptosis, inflammation, and disrupted cellular balance. This chapter explores the balance between autophagic activity and cellular health, emphasizing the need for precise regulation to harness autophagy's therapeutic potential. Recent studies highlight how autophagy interacts with mitochondrial dysfunction, reactive oxygen species, and inflammatory responses in SCI. Moreover, it discusses how natural compounds and nutraceuticals can modulate autophagy, offering promising strategies for managing consequences of SCI. Understanding autophagy is vital for advancing therapeutic interventions in SCI.
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