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Autophagy and Its Role in Neurodegenerative Diseases
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Author(s): Fatih Kara (Faculty of Medicine, Kafkas University, Turkey), Abdulsamet Mavzer (Faculty of Medicine, Kafkas University, Turkey), İrem Karalik (Faculty of Medicine, Kafkas University, Turkey)and Ayşe S. Baran (Faculty of Medicine, Kafkas University, Turkey)
Copyright: 2026
Pages: 26
Source title:
Autophagy and Inflammation in Neuropsychological Disorders
Source Author(s)/Editor(s): Tahmineh Mokhtari (Hubei University of Medicine, China)and Kadir Uludag (Shanghai Jiao Tong University, China)
DOI: 10.4018/979-8-3693-5908-2.ch001
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Abstract
Autophagy is an intrinsic cellular process whereby cells degrade their own constituents, enabling them to acquire vital components during periods of nutrient deprivation and to eliminate damaged organelles and misfolded proteins. Neurodegenerative diseases are predominantly characterized by the accumulation of protein aggregates and tend to be more common with advancing age. Given that autophagy becomes less effective with age and is crucial for maintaining cellular homeostasis, its potential link to neurodegenerative disorders raises significant questions. Moreover, since neurons are post-mitotic and possess limited regenerative capacity, they are particularly reliant on autophagic mechanisms to sustain their viability. Understanding the role of autophagy in neurodegenerative diseases is critical not only for elucidating the pathogenesis of these diseases but also for developing effective therapeutic interventions. This chapter elucidates the mechanisms underlying autophagy in the context of recent findings and underscores its role in the progression of neurodegenerative diseases.
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