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Pharmacological Significance of 1,2,3-Triazoles
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Author(s): Mubarak Hanif Shaikh (Radhabai Kale Mahila Mahavidyalaya, Ahmednagar, India), Amol A. Nagargoje (K.M.C. College of Arts, Science, and Commerce, Khopoli, India), Dattatraya N. Pansare (Deogiri College, India)and Bapurao B. Shingate (Dr. Babasaheb Ambedkar Marathwada University, India)
Copyright: 2025
Pages: 48
Source title:
Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications
Source Author(s)/Editor(s): Shrikaant Kulkarni (Sanjivani University, India & Victorian Institute of Technology, Australia), Hemantkumar Akolkar (Rayat Shikshan Sanstha’s Abasaheb Marathe Arts and New Commerce Science College, India), Bapurao B. Shingate (Dr. Babasaheb Ambedkar Marathwada University, India)and Vijay M. Khedkar (Vishwakarma University, India)
DOI: 10.4018/979-8-3693-7267-8.ch005
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Abstract
Click chemistry is not a single specific reaction, but was meant to mimic nature, which also generates substances by joining small modular units. The 1,3-dipolar azide, alkyne cycloaddition (CuAAC) reaction catalyzed by copper, as nearly quantitative and easy to execute has emerged as the leading example of “click chemistry”. Given the importance of the triazole scaffold in medicinal chemistry, its synthesis has attracted the attention of the drug discovery and development community. This book chapter will summarizes the major synthetic methods currently used for the preparation of triazole and pharmacological significance such as antifungal, antibacterial, antitubercular, anticancer, anti-inflammatory, antioxidant and many more properties will discussed. Furthermore, this book chapter will comprise the literature from 2020 to till date
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