Use of Ionic Liquids and DES for Synthesis of Medicinally Important 1,2,3-Triazole Scaffolds

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Author(s): Bishal Bhattacharyya (Dibrugarh University, India), Ramyata Priyam Borah (Dibrugarh University, India), Dipankar Nath (Dibrugarh University, India), Parishma Gogoi (Dibrugarh University, India)and Diganta Sarma (Dibrugarh University, India)
Copyright: 2025
Pages: 26
Source title: Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications
Source Author(s)/Editor(s): Shrikaant Kulkarni (Sanjivani University, India & Victorian Institute of Technology, Australia), Hemantkumar Akolkar (Rayat Shikshan Sanstha’s Abasaheb Marathe Arts and New Commerce Science College, India), Bapurao B. Shingate (Dr. Babasaheb Ambedkar Marathwada University, India)and Vijay M. Khedkar (Vishwakarma University, India)
DOI: 10.4018/979-8-3693-7267-8.ch004

Keywords: Chemical Engineering / Chemistry / Engineering Science Reference / Medicine & Healthcare

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Abstract

Cu catalysed azide alkyne cycloaddition reactions, known as click reactions, result in the regioselective formation of 1,4 disubstituted 1,2,3-triazoles. 1,2,3-triazoles are five membered nitrogen containing heterocycles that have gained much importance in recent times due to their various applications such as anti-cancer, anti- TB etc. Several greener approaches have been developed by different researchers to prepare 1,2,3-triazoles using benign methodologies. Greener solvents like Deep Eutectic Solvents (DES) and Ionic Liquids (IL) can serve as good alternative for volatile organic solvents used during azide alkyne cycloaddition reactions

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Use of Ionic Liquids and DES for Synthesis of Medicinally Important 1,2,3-Triazole Scaffolds

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