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Thiadiazoles: Chemistry and Biological Activities
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Author(s): G. Nagendra (REVA University, Bangalore, India), D. N. Akshitha (REVA University, Bangalore, India), H. S. Lalithamba (Siddaganga Institute of Technology, Tumakuru, India)and G. K. Prashanth (Sir M. Visvesvaraya Institute of Technology, Bengaluru, India)
Copyright: 2025
Pages: 40
Source title:
Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications
Source Author(s)/Editor(s): Shrikaant Kulkarni (Sanjivani University, India & Victorian Institute of Technology, Australia), Hemantkumar Akolkar (Rayat Shikshan Sanstha’s Abasaheb Marathe Arts and New Commerce Science College, India), Bapurao B. Shingate (Dr. Babasaheb Ambedkar Marathwada University, India)and Vijay M. Khedkar (Vishwakarma University, India)
DOI: 10.4018/979-8-3693-7267-8.ch013
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Abstract
Heterocycles containing nitrogen, oxygen and sulfur have been under investigation for a long time because of their important medicinal properties. The literature survey has described that thiadiazole moieties serve as analgesic, anti-inflammatory, anti-microbial activities, antihypertensive,anticancer, antituberculosis and vasodilator and this heterocyclic nucleus still possess considerable characteristics to attract the chemists for designing of newer biologically active molecules. Among them 1,2,4-thiadiazole, 1,3,4-thiadiazole and their derivatives are recognized as heterocyclic nuclei of great value in the field of medicinal chemistry. As a heterocyclic unit in a peptidomimetics might add conformational limitations to the structure, influencing the structure-activity-relationship. In this chapter, we are focusing on the synthetic strategies of 1,2,3-thiadiazole, 1,2,5-thiadiazole, 1,2,4-thiadiazole, 1,3,4-thiadiazole and their application in the industrial and biomedical fields.
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