The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
Polyphenol-Rich Formulations and Their Multi-Target Interactions With Molecular Pathways in Cancer Cells
|
|
Author(s): Emmanuel Henry Ezenabor (Bowen University, Nigeria), Aminat Abisola Afolabi (Bowen University, Nigeria), Oluwafemi Adeleke Ojo (University of Turku, Finland)and Oluyomi Stephen Adeyemi (Bowen University, Nigeria)
Copyright: 2026
Pages: 30
Source title:
Pharmacology, Characterizations, Toxicity, and Herb-Drug Interactions of Herbs in Traditional Medicine
Source Author(s)/Editor(s): Olubunmi Atolani (University of Ilorin, Nigeria), Learnmore Kambizi (Cape Peninsula University of Technology, South Africa)and M.T. Bakare-Odunola (University of Ilorin, Nigeria)
DOI: 10.4018/979-8-3373-5876-5.ch008
Purchase
|
Abstract
Cancer remains the second leading cause of death globally, with classical therapies limited by selectivity, toxicity, and resistance. This review examines polyphenol-rich preparations and their multi-target interactions in cancer cells. Polyphenols (flavonoids, phenolic acids, stilbenes, lignans) simultaneously modulate multiple targets, addressing key cancer hallmarks: sustained proliferative signaling, apoptosis evasion, replicative immortality, and angiogenesis. Key pathways include PI3K/Akt/mTOR, MAPK, RAS, and p53. Notable compounds like curcumin, resveratrol, quercetin, and EGCG induce apoptosis, inhibit angiogenesis, arrest cell cycle, and modulate epigenetics. Despite encouraging preclinical evidence, clinical translation faces challenges from low bioavailability, rapid metabolism, and conflicting data. Strategies include stable derivatives, nano-encapsulation, personalized medicine, and combination with established drugs. Polyphenolic compounds emerge as promising multi-target anticancer agents with low toxicity. Further research on bioavailability and trials is needed.
Related Content
|
Abisola Aminat Afolabi, Emmanuel Henry Ezenabor, Godwin Ayebaitari Berena.
© 2026.
34 pages.
|
|
Temidayo Daniel Adeniyi, Akinpelu Moronkeji, Godwin Olawoyin Adunmo, Gbadebo Maroof Oyeniyi, Emmanuel Tolulope Adegoke, Oluwadarasimi Osundara, Hanifat Abake Olaitan.
© 2026.
46 pages.
|
|
Sreya Kosanam, Revathi Boyina, A. M. T. Gurubasavaraj, K. M. D. Muzammil, R. Praveen Javali, Adinarayana Andy, Aman Suresh Tharayil.
© 2026.
38 pages.
|
|
Bui Thi Hao, Nguyen Thi Anh Hong, Nguyen Minh Khoi, Bui Thanh Tung.
© 2026.
18 pages.
|
|
Taye Temitope Alawode.
© 2026.
34 pages.
|
|
Damilare Rotimi, Victor Oluwadamilare Adeogun, Oluyomi Stephen Adeyemi.
© 2026.
26 pages.
|
|
Chhan Kumar Kalita, Awadhesh Kumar.
© 2026.
32 pages.
|
|
|