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Medicinal Ethnobotanicals in Mitigating Pollution-Induced Oxidative Damage With Mechanisms and Therapeutic Potential: Mechanistic Basis of Plant Antioxidant Defense
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Author(s): Temidayo Daniel Adeniyi (University of Ilorin, Nigeria), Akinpelu Moronkeji (Osun State University, Osogbo, Nigeria), Godwin Olawoyin Adunmo (University of Ilorin, Nigeria), Gbadebo Maroof Oyeniyi (University of Ilorin, Nigeria), Emmanuel Tolulope Adegoke (University of Ilorin, Nigeria), Oluwadarasimi Osundara (University of Ilorin, Nigeria)and Hanifat Abake Olaitan (University of Ilorin, Nigeria)
Copyright: 2026
Pages: 46
Source title:
Pharmacology, Characterizations, Toxicity, and Herb-Drug Interactions of Herbs in Traditional Medicine
Source Author(s)/Editor(s): Olubunmi Atolani (University of Ilorin, Nigeria), Learnmore Kambizi (Cape Peninsula University of Technology, South Africa)and M.T. Bakare-Odunola (University of Ilorin, Nigeria)
DOI: 10.4018/979-8-3373-5876-5.ch002
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Abstract
Environmental pollution remains a global health issue linked to numerous diseases, primarily through the generation of reactive oxygen species (ROS) that induce lipid peroxidation, protein and DNA damage, and cellular dysfunction. This review examines the therapeutic potential of medicinal ethnobotanicals in mitigating pollution-induced oxidative stress, with a focus on their molecular mechanisms and therapeutic potentials. Ethnobotanicals, rich in bioactive phytochemicals such as flavonoids, phenolic acids, alkaloids, and terpenoids, exhibit potent antioxidant and cytoprotective properties. Their protective effects are largely mediated through the enhancement of endogenous antioxidant systems and modulation of redox-sensitive signalling pathways. Evidence from both in vivo and in vitro studies highlights the efficacy of selected ethnobotanicals in reducing oxidative biomarkers and restoring tissue homeostasis, particularly in mammalian systems. This review highlights the potential of ethnobotanicals as promising agents in mitigating the health effects of environmental pollutants.
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