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Neurophytomedicine: A Critical Review of Traditional Herbal Anxiolytics
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Author(s): Sreya Kosanam (Dr. M.G.R. Educational and Research Institute, India), Revathi Boyina (QIS College of Pharmacy, India), A. M. T. Gurubasavaraj (YSS College of Pharmacy, India), K. M. D. Muzammil (YSS College of Pharmacy, India), R. Praveen Javali (Sri Raghavendra College of Pharmacy, Chitradurga, India), Adinarayana Andy (Weatherwax Family Pharmacies Inc., USA)and Aman Suresh Tharayil (Dr. M.G.R. Educational and Research Institute, India)
Copyright: 2026
Pages: 38
Source title:
Pharmacology, Characterizations, Toxicity, and Herb-Drug Interactions of Herbs in Traditional Medicine
Source Author(s)/Editor(s): Olubunmi Atolani (University of Ilorin, Nigeria), Learnmore Kambizi (Cape Peninsula University of Technology, South Africa)and M.T. Bakare-Odunola (University of Ilorin, Nigeria)
DOI: 10.4018/979-8-3373-5876-5.ch003
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Abstract
This chapter examines the scientific and clinical foundations of traditional herbal anxiolytics within the emerging field of neurophytomedicine. It explores the global prevalence and neurobiology of anxiety disorders, limitations of conventional pharmacological treatments, and the therapeutic potential of botanicals with historical use in anxiety relief. Emphasis is placed on phytochemical classes such as flavonoids, terpenes, alkaloids, and saponins, and their mechanisms of action on GABAergic, serotonergic, and hypothalamic pituitary adrenal systems. Comparative clinical evidence, safety considerations, herb-drug interactions, and regulatory frameworks are critically reviewed. The chapter also addresses challenges in standardization, placebo effects in trials, and ethical sourcing of medicinal plants. Finally, it outlines future directions including pharmacogenomic personalization, AI-driven phytochemical discovery, and integration of validated botanicals into mainstream psychiatry.
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