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Isoxazole: A Bioactive Five-Membered Heterocycle With Diverse Applications
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Author(s): Popat Mohite (AETs St. John Institute of Pharmacy and Research, Palghar, India), Savita Tauro (AETs St. John Institute of Pharmacy and Research, Palghar, India)and Aarati Pawar (AETs St. John Institute of Pharmacy and Research, Palghar, India)
Copyright: 2025
Pages: 26
Source title:
Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications
Source Author(s)/Editor(s): Shrikaant Kulkarni (Sanjivani University, India & Victorian Institute of Technology, Australia), Hemantkumar Akolkar (Rayat Shikshan Sanstha’s Abasaheb Marathe Arts and New Commerce Science College, India), Bapurao B. Shingate (Dr. Babasaheb Ambedkar Marathwada University, India)and Vijay M. Khedkar (Vishwakarma University, India)
DOI: 10.4018/979-8-3693-7267-8.ch003
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Abstract
Isoxazole is a versatile five-membered heterocyclic compound that has attracted significant attention due to its diverse medicinal chemistry and material science applications. This chapter provides a comprehensive overview of synthetic methodologies for preparing isoxazole derivatives, including traditional approaches such as cyclization reactions and modern techniques like microwave-assisted synthesis. The advantages and limitations of each method, highlighting the influence of structural variations on synthesis efficiency, are discussed. Furthermore, the biological activities associated with isoxazole compounds, showcasing their roles as potential pharmacological agents including anti-inflammatory, antibacterial, antifungal, and anticancer properties, are explored. By integrating synthetic strategies with biological evaluation, this chapter aims to illustrate the significance of isoxazole derivatives in drug discovery and development and their potential applications in therapeutic settings.
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