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Indazoles Chemistry and Biological Activities: Synthesis, Properties, and Biological Activities of Indazole
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Author(s): Navnath Tulshiram Hatvate (Institute of Chemical Technology, Mumbai, India), Khushbu Bagul (Institute of Chemical Technology, Marathwada, India), Nandini Anilsingh Gour (Institute of Chemical Technology, Marathwada, India)and Kalyani S. Sonawane (Institute of Chemical Technology, Marathwada, India)
Copyright: 2025
Pages: 52
Source title:
Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications
Source Author(s)/Editor(s): Shrikaant Kulkarni (Sanjivani University, India & Victorian Institute of Technology, Australia), Hemantkumar Akolkar (Rayat Shikshan Sanstha’s Abasaheb Marathe Arts and New Commerce Science College, India), Bapurao B. Shingate (Dr. Babasaheb Ambedkar Marathwada University, India)and Vijay M. Khedkar (Vishwakarma University, India)
DOI: 10.4018/979-8-3693-7267-8.ch006
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Abstract
In organic and medicinal chemistry research, indazole is an essential nitrogen-containing heterocyclic unit that is also a helpful precursor molecule for the synthesis of several kinds of heterocycles. The diverse tautomeric forms and unique chemical properties make it a versatile scaffold in medicinal chemistry. Indazole's relevance in the pharmaceutical industry is underscored by its presence in currently marketed drugs and investigational compounds, highlighting its therapeutic potential. In addition, the present ring structure has already been explored for diverse biological activity, including anti-microbial, anti-viral, anti-protozoal, anti-cancer, anti-inflammatory, analgesic, antipyretic, anti-oxidant, anti-convulsant, anti-depressant, anti-emetic, anti-diabetic, neuroprotective, antihypertensive, and anti-arrhythmic properties. This chapter comprehensively reviews indazole's synthesis, properties, and biological applications, along with an update on recent patents and ongoing clinical trials.
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