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Imidazo-Pyridines: A Hybrid N-Heterocycles for Their Sustainable Synthetic Approaches and Significant Clinical Diversity
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Author(s): Kartik Sanghavi (RK University, India), Bonny Y. Patel (RK University, India), Vijay Khedkar (Vishvkarma University, India)and Khushal M. Kapadiya (RK University, India)
Copyright: 2025
Pages: 60
Source title:
Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications
Source Author(s)/Editor(s): Shrikaant Kulkarni (Sanjivani University, India & Victorian Institute of Technology, Australia), Hemantkumar Akolkar (Rayat Shikshan Sanstha’s Abasaheb Marathe Arts and New Commerce Science College, India), Bapurao B. Shingate (Dr. Babasaheb Ambedkar Marathwada University, India)and Vijay M. Khedkar (Vishwakarma University, India)
DOI: 10.4018/979-8-3693-7267-8.ch011
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Abstract
The structural resemblance between the fused imidazopyridine heterocyclic ring system (a purine system) has prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial role in numerous disease conditions. In recent years, new preparative methods for the synthesis of imidazopyridines using various catalysts or non-catalytic systems have been described. In the present chapter, we summarise the recent approaches adopted for the synthesis of functionalized imidazo-pyridines over the last two decades along with their clinical advancement and applications. The key points adopted here including, traditional cyclo-condensation, reaction with nitro olefins, reaction with alkynes, 3-CCR (3-Component Condensation Reaction) based MCRs and miscellaneous aspects of imidazo-pyridine along with its biological importance have been presented and discussed. This chapter will provide new initiatives to the chemists towards the synthesis of imidazo-pyridines and possible medicinal applications with the reported methods.
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