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Genome Editing Technologies in Precision Medicine: Recent Innovations and Challenges

Genome Editing Technologies in Precision Medicine: Recent Innovations and Challenges
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Author(s): Kazi Asraf Ali (Maulana Abul Kalam Azad University of Technology, India), Rideb Chakraborty (Bengal College of Pharmaceutical Sciences and Research, India), Naureen Afrose (Bengal College of Pharmaceutical Sciences and Research, India), Chowdhury Mobaswar Hossain (Maulana Abul Kalam Azazd University of Technology, India), Amit Kotal (DmbH Institute of Medical Science, Dadpur, India)and Sourav Samanta (Maulana Abul Kalam Azazd University of Technology, India)
Copyright: 2026
Pages: 34
Source title: CRISPR-Cas9 Technology for Precision Medicine
Source Author(s)/Editor(s): Jen-Tsung Chen (National University of Kaohsiung, Taiwan)
DOI: 10.4018/979-8-3373-4857-5.ch001

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Abstract

Recent developments in genome editing technologies have revolutionized the field of genome precision medicine, offering unprecedented opportunities for genetic flaw correction, disease manipulation, and personalized treatment plans. These technologies include CRISPR-Cas systems, base editing, and prime editing, which can revolutionize treatments for monogenic disorders, cancers, and multifactorial complex diseases. However, challenges such as delivery bottlenecks, reactions, unintentional genetic changes, and ethical issues remain. The chapter emphasizes the need for improved viral and non-viral vectors, specificity tests, and efficient regulatory methods. It also addresses socioeconomic and accessibility concerns for equitable access to genome editing treatments. The chapter aims to balance innovation and responsible translation, considering both preclinical and clinical advances and current issues in genome editing in precision medicine.

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