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CRISPR-Cas9 Technology in Regenerative Medicine and Tissue Engineering
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Author(s): Arthi Gunasekaran (Bharathiar University, India), Muthupandi Vanaraj (Bharathiar University, India), Maria Sneha Philip Kumar (RVS College of Nursing, India), Abidharini Jothi Dheivasikamani (Bharathiar University, India), Arthi Boro (Bharathiar University, India), Antony Prabhu Jeyabal Philomenathan (Bharathiar University, India), Alwin Robert Asirvatham (Prince Sultan Military Medical City, Ministry of Defense, Saudi Arabia)and Vijaya Anand Arumugam (Bharathiar University, India)
Copyright: 2026
Pages: 34
Source title:
CRISPR-Cas9 Technology for Precision Medicine
Source Author(s)/Editor(s): Jen-Tsung Chen (National University of Kaohsiung, Taiwan)
DOI: 10.4018/979-8-3373-4857-5.ch006
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Abstract
CRISPR/Cas9 technology has emerged as a revolutionary genome editing tool, offering unprecedented precision, efficiency, and versatility in manipulating genetic material. In the fields of regenerative medicine and tissue engineering, CRISPR/Cas9 holds transformative potential for correcting genetic defects, enhancing stem cell therapies, engineering tissue specific cellular functions, and developing disease models. This chapter explores the fundamental mechanisms of CRISPR/Cas9, its integration into regenerative strategies and its application in engineering functional tissues and organs. Key advancements include targeted gene editing in induced pluripotent stem cells (iPSCs), modulation of signaling pathways involved in tissue regeneration and creation of gene-edited scaffolds for organogenesis. The chapter also addresses the current challenges, such as off-target effects, ethical considerations, and regulatory hurdles, while highlighting emerging innovations and future directions for clinical translation. Overall, CRISPR/Cas9 stands at the forefront of next-generation therapeutic strategies, reshaping the landscape of personalized and regenerative medicine.
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