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Aqua Mediated Multicomponent Synthesis of N, O-Heterocycles and Biological Activity of Fused Isoxazole Derivatives
Abstract
In the literature, several Drugs substituted with isoxazole ring shows various biological activities. The various drugs available in the market like sulfamethoxazole A, muscimol-B, ibotenic acid C, parecoxib-D, and leounomide contain the core structure of isoxazole. The use of water and phase transfer catalyst combined acted as a green attribute for the current approach. The current methodology has several benefits, such as a single-pot reaction, environmental friendliness, economic viability, wide substrate range, ease of operation, quick reaction time, simple workup process, and elevated yields. This chapter concentrates on the many antimicrobial characteristics of isoxazole derivatives, such as their analgesic, antitubercular, anticancer, and antibacterial qualities. We also report the synthesis of isoxazole derivatives using the aqua-mediated reaction of Chalcone hydroxylamine hydrochloride, and p-toluene sulfonic acid as catalyst.
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