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Therapeutic Implications of Chitosan and Its Derivatives: Focus on Cancer Treatment
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Author(s): Youssef Ait Hamdan (Cadi Ayyad University, Morocco & University of Rennes, France), Imade Armadi (Cadi Ayyad University, Morocco), khawla Rachmoune (Cadi Ayyad University, Morocco), Fatima Ezzahra Elamrani (Cadi Ayyad University, Morocco), Maryem Mekouar (Faculté de Médecine et de Pharmacie de Rabat, Morocco), Adil El Housseini (Ibn Zohr University, Morocco), Aicha Moufakkir (Chouaib Doukkali University, Morocco), Samia Elouali (Cadi Ayyad University, Morocco), Souad Loqman (Cadi Ayyad University, Morocco), Anass Belbachir (Laboratory of Innovations in Biotechnology, Pharmaceutical Bioengineering, and Artificial Intelligence, Morocco)and Mohammed Rhazi (Cadi Ayyad University, Morocco)
Copyright: 2026
Pages: 28
Source title:
Biomedical Applications and Toxicity of Polymers, Nanoparticles, Biomaterials, and Metal Ions
Source Author(s)/Editor(s): Deniz Eren Erişen (Institute of Semiconductors, Guangdong Academy of Sciences, China), Faez Iqbal Khan (Xi’an Jiaotong-Liverpool University, China), Cheng Chang (Institute of New Materials, Guangdong Academy of Sciences, China & University of Birmingham, UK)and Kai-Cheng Yan (University of Bath, UK)
DOI: 10.4018/979-8-3373-0055-9.ch009
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Abstract
Chitosan and its derivatives have garnered increasing interest in oncology due to their unique properties, such as biocompatibility, bioactivity and their ability to interact with molecules. These characteristics make them promising candidates for the development of novel anticancer therapies. Chitosan can be employed as drug delivery systems, enhancing the availability and targeted release of therapeutic agents into cancer cells. Additionally, they have demonstrated the ability to inhibit cell proliferation, induce apoptosis, and modulate immune responses, positioning them as multifunctional tools in the fight against cancer. Recent research has focused on the development of chitosan-based nanoparticles for targeted drug delivery in chemotherapy, reducing side effects on healthy cells. Furthermore, Chitosan systems have been used to deliver siRNA and other therapeutic molecules, inhibiting tumor growth at the genetic level. These advancements highlight chitosan's potential in developing more effective and less toxic cancer treatments.
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