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Single-Cell Approaches in Pulmonary Disease
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Author(s): Rahul Kumar (Department of Microbiology, Graphic Era University, Dehradun, India), Rachan Karmakar (Department of Environmental Science, Graphic Era University, Dehradun, India), Sanja Živković (University of Niš, Serbia)and Tanja Vasić (University of Niš, Serbia)
Copyright: 2026
Pages: 42
Source title:
Next-Generation Bioinformatics for Pulmonary Disease Research
Source Author(s)/Editor(s): Devvret Verma (Graphic Era University, India), Debasis Mitra (Graphic Era University, India), Bhavya Mudgal (Graphic Era University, India), Suraj Vitthaloo Atram (The University of Sheffield, UK)and Rokayya Sami (Taif University, Saudi Arabia)
DOI: 10.4018/979-8-3373-4923-7.ch003
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Abstract
Pulmonary disorders asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and infections are also characterized by intricate cellular heterogeneity and dynamic microenvironments. Traditional bulk profiling important cellular variations that underlie disease initiation, progression, and therapeutic responses. Recent technical advances in single-cell methodologies, including single-cell RNA sequencing (scRNA-seq), mass cytometry, and spatial transcriptomics, have revolutionized the field of pulmonary biology by allowing the detection of low-abundance cell subsets, new biomarkers, and cell-to-cell interactions in lungs. These methods have uncovered immune epithelial crosstalk, cellular plasticity, and as-yet-unrecognized pathogenic subsets that mediate inflammation and tissue remodeling. In single-cell atlases of healthy and diseased lungs revealed unprecedented molecular signatures, opening the door to precision medicine in respiratory health. In this chapter, principles, applications, and future directions of single-cell strategies in pulmonary disease are discussed.
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