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Radioprotective Effects of Chitosan Polysaccharides and Biomedical Applications
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Author(s): Khawla Rachmoune (Université Claude Bernard Lyon, France), Saloua Mabsor-Zgandaoui (Biology and Health Laboratory, Department of Biology, Faculty of Sciences, Ibn Tofail University, Morocco), Adil El Housseini (Laboratory Marine and Continental Environments (AQUAMAR), Faculty of Sciences, Ibn Zohr University, Morocco), Youssef Ait Hamdan (Cadi Ayyad University, Morocco), Maryam Bousaid (Laboratory of Materials Science and Composite Polymers(SMPC), UMONS, Belgium), Adil Aknouch (LICPM Laboratory, Department of Physics, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Morocco), Mohammed Rhazi (Higher Normal School, Cadi Ayyad University, Morocco), Adem Gharsallaoui (Université Claude Bernard Lyon, France), Abdelghani Iddar (Biotechnology and Biomolecules Engineering Unit, CNESTEN, Morocco), Mohammed El Mzibri (Biotechnology and Biomolecules Engineering Unit, CNESTEN, Morocco), Ahmed Moussaif (Biotechnology and Biomolecules Engineering Unit, CNESTEN, Morocco), El Hassan El Mouden (Laboratory of Water, Biodiversity and Climate Change, Faculty of Sciences Semlalia, Morocco)and Adnane Moutaouakkil (Biotechnology and Biomolecules Engineering Unit, CNESTEN, Morocco)
Copyright: 2026
Pages: 24
Source title:
Biomedical Applications and Toxicity of Polymers, Nanoparticles, Biomaterials, and Metal Ions
Source Author(s)/Editor(s): Deniz Eren Erişen (Institute of Semiconductors, Guangdong Academy of Sciences, China), Faez Iqbal Khan (Xi’an Jiaotong-Liverpool University, China), Cheng Chang (Institute of New Materials, Guangdong Academy of Sciences, China & University of Birmingham, UK)and Kai-Cheng Yan (University of Bath, UK)
DOI: 10.4018/979-8-3373-0055-9.ch010
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Abstract
Ionizing radiation (IR) plays a central role in the biomedical field, both for diagnosis and for the treatment of pathologies such as cancer. However, exposure to IR can cause significant cellular damage, affecting both tumor cells and neighbouring healthy tissue. In this context, the use of effective radioprotective agents is a necessity. Chitosan (CS), a natural biopolymer derived from chitin, stands out for its antioxidant, anti-inflammatory and reparative properties, as well as its biocompatibility and biodegradability. These characteristics make it a promising candidate for radiation protection. This chapter examines the radioprotective mechanisms of chitosan, in particular its ability to trap reactive oxygen species and enhance the activity of antioxidant enzymes. It also highlights its many biomedical applications, particularly in tissue engineering and controlled drug release. Finally, the limits to its clinical use and recent advances aimed at improving its physico-chemical properties are discussed, paving the way for new therapeutic strategies in radiation protection.
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