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Modularity of Biochemical Networks
Abstract
To reveal the relationships between large-scale, heterogeneous biochemical networks and their associated functions, called design principles in biology, it is critically important to disintegrate the networks into topology- or function-based subnetworks to analyze the mechanism of how each subnetwork generates a specific biological function, and to synthesize them as the whole system in the same manner as engineering, where a variety of parts are assembled into functional machines. This synthesis and analysis approach can be carried out by a computer. In this review, the author describes several methodologies that serve to disintegrate biological systems into biologically meaningful modules, with practical consequences for systems biology studies.
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