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Methods for Reverse Engineering of Gene Regulatory Networks

Methods for Reverse Engineering of Gene Regulatory Networks
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Author(s): Hendrik Hache (Max Planck Institute for Molecular Genetics, Germany)
Copyright: 2009
Pages: 19
Source title: Handbook of Research on Systems Biology Applications in Medicine
Source Author(s)/Editor(s): Andriani Daskalaki (Max Planck Institute for Molecular Genetics, Germany)
DOI: 10.4018/978-1-60566-076-9.ch029

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Abstract

In this chapter, different methods and applications for reverse engineering of gene regulatory networks that have been developed in recent years are discussed and compared. Inferring gene networks from different kinds of experimental data are a challenging task that emerged, especially with the development of high throughput technologies. Various computational methods based on diverse principles were introduced to identify new regulations among genes. Mathematical aspects of the models are highlighted, and applications for reverse engineering are mentioned.

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