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Insights on the Role of the Microbiome in Influencing Cancer Risk: How Ecological Exposures Affect Microbiome in Influencing Cancer Risk
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Author(s): Joyjyoti Das (Adamas University, Kolkata, India), Bandana Padhan (Adamas University, Kolkata, India), Anjali Sadhukhan (Adamas University, Kolkata, India), Ritika Halder (Adamas University, Kolkata, India), Swetashree Purohit (C.V. Raman Global University, India)and Tania Aich (Adamas University, Kolkata, India)
Copyright: 2026
Pages: 38
Source title:
Cancer Exposomics and Environmental Influences on Carcinogenesis
Source Author(s)/Editor(s): Ramya Raghavan (Sri Sathya Sai University for Human Excellence, India)
DOI: 10.4018/979-8-3373-2165-3.ch005
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Abstract
The microbiome refers to the complex community of microorganisms dwelling in and on the human body. Especially, the gut microbiota is involved in modulating a host of crucial physiological processes such as immunity development, anabolism, and nutrient uptake. Diverse ecological exposures ranging from environmental pollutants to dietary components and infectious agents may influence the microbiome to either promote carcinogenesis by inducing chronic inflammation and producing toxic metabolites or exert anticancer effects by boosting the host immune response. This chapter accounts for the various exposomes and their role in influencing microbiome-mediated cancer risk, the mechanisms involved, and the various novel strategies that are being established by researchers for cancer prevention, early detection, and therapeutic interventions via the microbiome-alteration route. The role of advanced technologies such as metagenomics and NGS in enhancing the understanding of the microbiome-carcinogenesis crosstalk has also been discussed with the hope of fostering research in this domain.
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