The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
Genome-Wide Analysis of Epistasis Using Multifactor Dimensionality Reduction: Feature Selection and Construction in the Domain of Human Genetics
Abstract
Human genetics is an evolving discipline that is being driven by rapid advances in technologies that make it possible to measure enormous quantities of genetic information. An important goal of human genetics is to understand the mapping relationship between interindividual variation in DNA sequences (i.e., the genome) and variability in disease susceptibility (i.e., the phenotype). The focus of the present study is the detection and characterization of nonlinear interactions among DNA sequence variations in human populations using data mining and machine learning methods. We first review the concept difficulty and then review a multifactor dimensionality reduction (MDR) approach that was developed specifically for this domain. We then present some ideas about how to scale the MDR approach to datasets with thousands of attributes (i.e., genome-wide analysis). Finally, we end with some ideas about how nonlinear genetic models might be statistically interpreted to facilitate making biological inferences.
Related Content
|
David Edson Ribeiro, Valter Augusto de Freitas Barbosa, Clarisse Lins de Lima, Ricardo Emmanuel de Souza, Wellington Pinheiro dos Santos.
© 2021.
15 pages.
|
|
Juliana Carneiro Gomes, Maíra Araújo de Santana, Clarisse Lins de Lima, Ricardo Emmanuel de Souza, Wellington Pinheiro dos Santos.
© 2021.
12 pages.
|
|
Maíra Araújo de Santana, Jessiane Mônica Silva Pereira, Clarisse Lins de Lima, Maria Beatriz Jacinto de Almeida, José Filipe Silva de Andrade, Thifany Ketuli Silva de Souza, Rita de Cássia Fernandes de Lima, Wellington Pinheiro dos Santos.
© 2021.
19 pages.
|
|
Jessiane Mônica Silva Pereira, Maíra Araújo de Santana, Clarisse Lins de Lima, Rita de Cássia Fernandes de Lima, Sidney Marlon Lopes de Lima, Wellington Pinheiro dos Santos.
© 2021.
25 pages.
|
|
Adriel dos Santos Araujo, Roger Resmini, Maira Beatriz Hernandez Moran, Milena Henriques de Sousa Issa, Aura Conci.
© 2021.
35 pages.
|
|
Abir Baâzaoui, Walid Barhoumi.
© 2021.
21 pages.
|
|
Marcus Costa de Araújo, Luciete Alves Bezerra, Kamila Fernanda Ferreira da Cunha Queiroz, Nadja A. Espíndola, Ladjane Coelho dos Santos, Francisco George S. Santos, Rita de Cássia Fernandes de Lima.
© 2021.
44 pages.
|
|
|