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Discrete Networks as a Suitable Approach for the Analysis of Genetic Regulation

Discrete Networks as a Suitable Approach for the Analysis of Genetic Regulation
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Author(s): Elizabeth Santiago-Cortés (Universidad Nacional Autónoma de México, Mexico)
Copyright: 2009
Pages: 11
Source title: Handbook of Research on Systems Biology Applications in Medicine
Source Author(s)/Editor(s): Andriani Daskalaki (Max Planck Institute for Molecular Genetics, Germany)
DOI: 10.4018/978-1-60566-076-9.ch031

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Abstract

Biological systems are composed of multiple interacting elements; in particular, genetic regulatory networks are formed by genes and their interactions mediated by transcription factors. The establishment of such networks is critical to guarantee the reliability of transcriptional performance in any organism. The study of genetic regulatory networks as dynamical systems is a helpful methodology to understand the transcriptional behavior of the genome. From a number of theoretical studies, it is known that networks present a complex dynamical behavior that includes stability, redundancy, homeostasis, and multistationarity. In this chapter we present some particular biological processes modeled as discrete networks to show that the theoretical properties of networks have a clear biological interpretation.

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