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Biomedical Application of Multimodal Ultrasound Microscope
Abstract
High frequency ultrasound imaging has evolved from the classical acoustic microscope to the multimodal ultrasound microscope, which is available for quantitative C-mode, surface acoustic impedance mode, and three-dimensional (3D)-mode imaging. This evolution has realized both quantitative parametric imaging and easier observation. Quantitative C-mode represents two-dimensional sound speed distribution and is realized by frequency-domain analysis of a single pulse by a high-speed digitizer. Because the square of sound speed is proportional to tissue elasticity, sound speed imaging provides biomechanical information about the tissue. Surface acoustic impedance mode has been used to image fresh brain tissue. High-frequency 3D-mode imaging has been used to visualize the 3D structure of dermis sebaceous glands.
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