Synthesis, Characterizations, and Biological Effects Study of Some Quinoline Family

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Author(s): Messai Amel (Laboratoire d'Ingénierie et Sciences des Matériaux Avancés (ISMA) Institut des Sciences et Technologie Abbès Laghrour University Khenchela; 40000, Algeria)
Copyright: 2016
Pages: 37
Source title: Emerging Research on Bioinspired Materials Engineering
Source Author(s)/Editor(s): Mohamed Bououdina (University of Bahrain, Bahrain)
DOI: 10.4018/978-1-4666-9811-6.ch006

Keywords: Engineering Science Reference / Materials Science / Materials Science and Engineering / Science & Engineering

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Abstract

The objective of this work is the synthesis of new quinoline molecules which could have some biological activities. This chapter reported a new approach to the synthesis of some quinoline derivatives. The Baylis-Hillman reaction on 2-methoxy-3-formyl quinoléines derivatives have applied in order to obtain Baylis-Hillman adducts. The products are characterized by FTIR, NMR and X-ray single crystal diffraction .Also, a study of the antibacterial activity of the 3-(2-chloro quinoline)-3-hydroxy-2 methylene propanonitrile products synthesized have been explored. This assessment is made by using the disk diffusion method. The results showed that the 3-(2'-chloroquinoline)-3-hydroxy-2-methylenepropanonitril derivatives present a good antibacterial effectiveness against the strains tested Gram-positive and no antibacterial potency was observed against the stains Gram-negative used in the test.

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Synthesis, Characterizations, and Biological Effects Study of Some Quinoline Family

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