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Computer Simulation Studies of Non-Thermal Plasma in Cancer Treatment: Understanding Protein Modifications for Enhanced Therapeutic Efficacy
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Author(s): Davronjon Abduvokhidov (R&D Center, New Uzbekistan University, Uzbekistan & Department of Information Technologies, Tashkent International University of Education, Uzbekistan & Institute of Material Sciences, Academy of Sciences, Uzbekistan), Zhitong Chen (Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China & Center for Advanced Therapy, National Innovation Center for Advanced Medical Devices, China)and Jamoliddin Razzokov (Institute of Fundamental and Applied Research, National Research University TIIAME, Uzbekistan & School of Engineering, Central Asian University, Uzbekistan & Department of Biomedical Engineering, Tashkent State Technical University, Uzbekistan)
Copyright: 2024
Pages: 16
Source title:
Emerging Applications of Plasma Science in Allied Technologies
Source Author(s)/Editor(s): Aamir Shahzad (Government College University, Faisalabad, Pakistan)and Maogang He (Xi'an Jiaotong University, China)
DOI: 10.4018/979-8-3693-0904-9.ch004
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Abstract
Non-thermal plasma (NTP), the fourth state of matter, holds promise in altering biological matter, particularly in cancer treatment. NTP influences cell signaling by modifying key components, such as membranes, proteins, and DNA. It selectively targets cancer cells through the generation of reactive oxygen and nitrogen species (RONS), which modify amino acids within proteins. Understanding these molecular mechanisms is vital for optimizing NTP's potential in oncology. This book chapter reviews recent computer simulations and experimental findings exploring NTP's impact on proteins in cancer therapy, providing insights into how protein modifications affect cancer cell behavior and therapy responses. This knowledge advances NTP-based cancer treatments, offering the potential for personalized and targeted therapies in the future.
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