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ROS and Precision Medicine in Lifestyle Diseases: Personalized Approaches
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Author(s): Pawan Gupta (Department of Pharmaceutical Chemistry, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, India), Yogesh Chaudhari (Department of Pharmaceutical Chemistry, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, India), Abhinav Joseph (School of Chemical Engineering and Physical Sciences, Lovely Professional University, India & St. John's College, Agra, India), Sukrat Sinha (Department of Zoology, University of Delhi, India), Ansari Rashid (Department of Pharmacology, Sanjay Education Society's Institute of Pharmacology, India)and Pranav Kumar Prabhakar (Lovely Professional University, India & Nagaland University, India)
Copyright: 2025
Pages: 34
Source title:
The Role of Reactive Oxygen Species in Human Health and Disease
Source Author(s)/Editor(s): Pranav Kumar Prabhakar (Department of Biotechnology, Nagaland University, India)
DOI: 10.4018/979-8-3693-7919-6.ch013
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Abstract
The body's cells produce highly reactive substances known as reactive oxygen species (ROS). Though ROS are important in immunological responses as well as metabolic pathways. However, high concentrations bring about oxidative stress, which lead to many lifestyle diseases such as diabetes, heart diseases, etc. This chapter examines involvement of the ROS in mechanism of disease initiation, and how the dynamic nature of the individual ROS might open the options for personalized treatment. Moreover, it is also examined how differences in genotype with respect to important enzymes, could influence life style diseases. Interactions with genes in explaining responses to drug therapy are exemplified in the context of diabetes, cancer, and inflammatory diseases. These findings offer contributions to controlling oxidative stress and related disorders through growing approaches for templatized strategies from within a better awareness of ROS and other genetic factors.
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