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Proteomics and Related Applications in Oral Cancer and Sjögren's Syndrome
Abstract
Proteomics is the study of a complete set of proteins present in a biological system using the technologies of large-scale protein separation and identification. It is a powerful approach for biomedical research because it aims for a comprehensive, quantitative analysis of protein expression and its changes under biological perturbations such as disease or drug treatment. The purpose of this book chapter is to give an overview of proteomics using mass spectrometry and protein microarrays and to discuss related applications of proteomics in oral cancer and Sjögren’s syndrome. Proteomics may significantly accelerate the oral disease research by providing a novel molecular technology to discover protein biomarkers for disease diagnosis/prognosis, to elucidate the molecular determinants underlying the disease mechanism, and to identify novel targets for therapeutic intervention.
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