Creator of Knowledge
Information Resources Management Association
Advancing the Concepts & Practices of Information Resources Management in Modern Organizations

Immunogenicity of Stem Cells

Immunogenicity of Stem Cells
View Sample PDF
Author(s): Franz Ricklefs (University Heart Center Hamburg, Germany)and Sonja Schrepfer (University Heart Center Hamburg, Germany)
Copyright: 2013
Pages: 16
Source title: Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications
Source Author(s)/Editor(s): Andriani Daskalaki (Max Planck Institute for Molecular Genetics, Germany)
DOI: 10.4018/978-1-4666-2506-8.ch005


View Immunogenicity of Stem Cells on the publisher's website for pricing and purchasing information.


Current medical research is focused on two particular types of stem cells, adult stem cells and embryonic stem cells. Both cell types demonstrate a tremendous potential as the source for regenerative medicine due to their paracrine and pluripotency effects, respectively. Therefore, stem cells are expected to have an enormous impact on clinical therapy. However, allogeneic approaches using “off-the-shelf” stem cells from healthy donors are the only financially and ethically feasible pathway. The long-standing assumption that stem cells are not recognized by the recipient’s immune system was recently disproved not only by our group. Therefore, specific knowledge of the immunologic properties of pluripotent and multipotent stem cells is a prerequisite for safe applications of stem cell-based therapy. This chapter will discuss the involvement of the innate and adaptive immune system and summarize state-of-the art approaches to overcome the immunological barrier.

Related Content

Julia Zimmer, Elisa Degenkolbe, Britt Wildemann, Petra Seemann. © 2013. 30 pages.
George I. Lambrou, Maria Adamaki, Apostolos Zaravinos. © 2013. 22 pages.
Svetoslav Nikolov, Mukhtar Ullah, Momchil Nenov, Julio Vera Gonzalez, Peter Raasch, Olaf Wolkenhauer. © 2013. 23 pages.
Ana M. Sotoca, Michael Weber, Everardus J. J. van Zoelen. © 2013. 19 pages.
Franz Ricklefs, Sonja Schrepfer. © 2013. 16 pages.
Sonja Schallenberg, Cathleen Petzold, Julia Riewaldt, Karsten Kretschmer. © 2013. 25 pages.
Ali Mobasheri. © 2013. 32 pages.
Body Bottom