The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
Prioritizing Disease Genes and Understanding Disease Pathways
|
|
Author(s): Xiaoyue Zhao (Bionovo Inc., USA), Lilia M. Iakoucheva (Rockefeller University, USA)and Michael Q. Zhang (Cold Spring Harbor Laboratory, USA)
Copyright: 2009
Pages: 18
Source title:
Biological Data Mining in Protein Interaction Networks
Source Author(s)/Editor(s): Xiao-Li Li (Institute for Infocomm Research, A* STAR, Singapore)and See-Kiong Ng (Institute for Infocomm Research, A* STAR, Singapore)
DOI: 10.4018/978-1-60566-398-2.ch014
Purchase
|
Abstract
Genetic factors play a major role in the etiology of many human diseases. Genome-wide experimental methods produce an increasing number of genes associated with such diseases. This chapter introduces data sources, bioinformatics tools, and computational methods for prioritizing disease candidate genes and identifying disease pathways. The main strategy is to examine the similarity among the candidate genes and known disease genes at the functional level. The authors review different similarity measures and prevailing methods for integrating results from different functional aspects. They hope this chapter will help advocate many useful resources that the researchers can use to investigate diseases of their interest.
Related Content
|
Rahul Kumar, Devvret Verma, Bahman Khoshru, Adeyemi Nurudeen Olatunbosun.
© 2026.
36 pages.
|
|
S. Ida Evangeline.
© 2026.
34 pages.
|
|
Rahul Kumar, Rachan Karmakar, Sanja Živković, Tanja Vasić.
© 2026.
42 pages.
|
|
Poonam K. Verma, Nisha Chandran.
© 2026.
20 pages.
|
|
Odangowei Inetiminebi Ogidi, Shoheb Shakil Shaikh, Mukul Machhindra Barwant.
© 2026.
42 pages.
|
|
Harsh Virendrabhai Purohit, Veda Pandya.
© 2026.
30 pages.
|
|
Rachan Karmakar, Divya Gunsola, Debasis Mitra, Viralkumar B. Mandaliya, Arti Thakur, Addisu Assefa, Sourav Chattaraj, Mukul Machhindra Barwant, Uma Eswaranpillai, Ponmurugan Karuppiah.
© 2026.
28 pages.
|
|
|