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Microbiome and Brain-Gut Microbiota's Influence on Autism Pathogenesis
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Author(s): Aman Babanrao Upaganlawar (SNJB's Shriman Sureshdada Jain College of Pharmacy, India), Nitu Wankhede (Smt. Kishoritai Bhoyar College of Pharmacy, India), Mayur Kale (Smt. Kishoritai Bhoyar College of Pharmacy, India), Sandip Rahangdale (Smt. Kishoritai Bhoyar College of Pharmacy, India), Manish Aglawe (Smt. Kishoritai Bhoyar College of Pharmacy, India), Brijesh Taksande (Smt. Kishoritai Bhoyar College of Pharmacy, India)and Milind Umekar (Smt. Kishoritai Bhoyar College of Pharmacy, India)
Copyright: 2025
Pages: 34
Source title:
Empowering Innovations in Advanced Autism Research and Management
Source Author(s)/Editor(s): Athanasios Alexiou (Department of Research and Development, Funogen, Athens, Greece & Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, Australia), Ghulam Md Ashraf (Department of Biosciences and Bioinformatics, School of Science, Xi’an Jiaotong-Liverpool University, China)and Markos Sgantzos (University of Thessaly, Greece & Hellenic Physical and Rehabilitation Medicine Society, Greece)
DOI: 10.4018/979-8-3693-8176-2.ch004
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Abstract
Autism Spectrum Disorders (ASD) are neurodevelopmental conditions characterized by social communication challenges and repetitive behaviors. Emerging evidence suggests that gut microbiota, through the gut-brain axis, play a significant role in ASD pathogenesis. This complex communication network influences neurodevelopment by modulating immune responses, producing neuroactive metabolites, and maintaining gut barrier integrity. In individuals with ASD, specific microbial imbalances and reduced diversity are commonly observed, which are linked to these pathophysiological processes. Genetic predispositions and environmental factors, such as diet and antibiotic use, further affect gut microbiota composition, potentially exacerbating these imbalances. Therapeutic strategies targeting the gut microbiota, including probiotics, prebiotics, dietary modifications, and fecal microbiota transplantation, have shown potential in alleviating ASD symptoms. This chapter provides a comprehensive overview of the current understanding of the gut microbiota's role in ASD.
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