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Macrolide's Anti-Inflammatory Effects on Acute and Subacute Inflammation (Azithromycin, Clarithromycin, and Roxithromycin)
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Author(s): Vandana M. Thorat (Krishna Institute of Medical Sciences, India)and Mahesh Manohar Bharambe (Krishna Vishwa Vidyapeeth, India)
Copyright: 2023
Pages: 16
Source title:
Advances in Artificial and Human Intelligence in the Modern Era
Source Author(s)/Editor(s): S. Suman Rajest (Dhaanish Ahmed College of Engineering, India), Bhopendra Singh (Amity University, Dubai, UAE), Ahmed J. Obaid (University of Kufa, Iraq), R. Regin (SRM Institute of Science and Technology, India)and Karthikeyan Chinnusamy (Veritas, USA)
DOI: 10.4018/979-8-3693-1301-5.ch018
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Abstract
The key characteristics of acute inflammation are the exudation of fluid and plasma proteins and the emigration of leukocytes, mostly neutrophils, and it often begins within minutes or hours in response to infection and tissue damage and lasts for many hours. After the harmful agents have been removed, the acute inflammatory response fades, but if the response fails to eradicate the stimuli, the reaction might develop into a prolonged phase referred to as chronic inflammation. Since there is no safe, effective anti-inflammatory drug, scientists continue to study inflammation. Azithromycin, Clarithromycin, and Roxithromycin were tested for anti-inflammatory properties in Wistar rats with acute and sub-acute inflammation. Karad's largest animal house supplied 200–300g Wistar rats. Before the studies, the animals were used to the 24-hour cycle of light and dark for ten days. There was generally enough water and rat pellets. The IAC authorised this study (Institutional Animal Ethics Committee).
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