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Knowledge-Based Induction of Clinical Prediction Rules
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Author(s): Mila Kwiatkowska (Thompson Rivers University, Canada), M. Stella Atkins (Simon Fraser University, Canada), Les Matthews (Thompson Rivers University, Canada), Najib T. Ayas (University of British Columbia, Canada)and C. Frank Ryan (University of British Columbia, Canada)
Copyright: 2009
Pages: 26
Source title:
Data Mining and Medical Knowledge Management: Cases and Applications
Source Author(s)/Editor(s): Petr Berka (University of Economics, Prague, Czech Republic), Jan Rauch (University of Economics, Prague, Czech Republic)and Djamel Abdelkader Zighed (University of Lumiere Lyon 2, France)
DOI: 10.4018/978-1-60566-218-3.ch017
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Abstract
This chapter describes how to integrate medical knowledge with purely inductive (data-driven) methods for the creation of clinical prediction rules. It addresses three issues: representation of medical knowledge, secondary analysis of medical data, and evaluation of automatically induced predictive models in the context of existing knowledge. To address the complexity of the domain knowledge, the authors have introduced a semio-fuzzy framework, which has its theoretical foundations in semiotics and fuzzy logic. This integrative framework has been applied to the creation of clinical prediction rules for the diagnosis of obstructive sleep apnea, a serious and under-diagnosed respiratory disorder. The authors use a semio-fuzzy approach (1) to construct a knowledge base for the definition of diagnostic criteria, predictors, and existing prediction rules; (2) to describe and analyze data sets used in the data mining process; and (3) to interpret the induced models in terms of confirmation, contradiction, and contribution to existing knowledge.
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