Intracellular Behavior of Nanoparticles Based on their Physicochemical Properties

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Author(s): Charmainne Cruje (Ryerson University, Canada), Darren Yohan (Ryerson University, Canada), Celina Yang (Ryerson University, Canada)and Devika B. Chithrani (Ryerson University, Canada)
Copyright: 2015
Pages: 26
Source title: Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering
Source Author(s)/Editor(s): Shivani Soni (Alabama State University, USA), Amandeep Salhotra (City of Hope National Medical Center, USA)and Mrutyunjay Suar (KIIT University, India)
DOI: 10.4018/978-1-4666-6363-3.ch002

Keywords: Computer Science & IT / Engineering Science / Engineering Science Reference / Nanotechnology

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Abstract

This chapter addresses physicochemical properties that affect Nanoparticle (NP) intracellular behavior using Gold NPs (GNPs) as a model system. The main objective is to outline what is known about the effect of GNP size, shape, and surface properties on cellular uptake and intracellular pathway. The authors propose that the entry of GNPs into cells is related to its effectiveness in applications that favor intracellular localization of such GNPs. The authors also discuss how such properties are used to optimize GNP designs for medical applications. Finally, the authors discuss how GNPs may improve disease diagnosis and treatment. Furthermore, how they may be incorporated or used as alternatives to current treatment options is defined.

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Intracellular Behavior of Nanoparticles Based on their Physicochemical Properties

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