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Discovering Protein-Protein Interaction Sites from Sequence and Structure
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Author(s): David La (Purdue University, USA)and Daisuke Kihara (Purdue University, USA)
Copyright: 2009
Pages: 16
Source title:
Biological Data Mining in Protein Interaction Networks
Source Author(s)/Editor(s): Xiao-Li Li (Institute for Infocomm Research, A* STAR, Singapore)and See-Kiong Ng (Institute for Infocomm Research, A* STAR, Singapore)
DOI: 10.4018/978-1-60566-398-2.ch005
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Abstract
This chapter gives a comprehensive introduction of the sequence/structural features that are characteristic of protein- protein interaction sites and reviews state-of-the-art methodologies for protein-protein binding site prediction. Protein-protein interaction residues are largely responsible for mediating physical binding processes such as inhibitory effects through enzyme-inhibitor interaction, initiating immune response by an antibody-antigen interaction, and regulation of cell signaling proteins. Currently, various methods are available for predicting protein-protein interaction sites, which allow a residue-level understanding of the physical protein binding phenomena presented by the global construction protein-protein interaction networks. The overview of the discussed protein-protein binding site prediction strategies and detailed comparison of their weaknesses and strengths is aimed towards assisting protein researchers in gaining more insight to protein-protein interaction networks.
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