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Dietary Supplements Functions as Improved Immunity in Nutritional Deficiency Autoimmune Disorders Considerations: Mycobacterium Tuberculosis Induced RA With LCPUFA-DHA in Mice
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Author(s): Zuber Peermohammed Shaikh (University of Pune, India)and Satish Balkrishna Bhise (Sinhgad Institute's Smt. Kashibai Navale College of Pharmacy, Pune, India)
Copyright: 2024
Pages: 30
Source title:
Nutrition Controversies and Advances in Autoimmune Disease
Source Author(s)/Editor(s): Srikanta Patnaik (SOA University, India & Interscience Institute of Management and Technology, India), Ahmed M. Hamad (Benha University, Egypt), Debjyoti Paul (Amity University, Kolkata, India), Pushan Kumar Dutta (Amity University, Kolkata, India)and Muhammad Shafiq (Guangzhou University, China & Shenyang Normal University, China)
DOI: 10.4018/979-8-3693-5528-2.ch016
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Abstract
The immune system is highly toned and efficiently dedicated to maintaining health by protecting against a tremendous array of invaders. A possible explanation may be that mice with the mycobacterium tuberculosis induced rheumatoid arthritis may be better primed for improved n-3-LCPUFA utilization due to their prior deficiency status. The authors showed that EPA/DHA supplementation in mice with sufficient n-3-PUFA status did not interfere with the TB drug treatment when co-administered as an adjunct therapy. A similar trend was observed when mice with low n-3-PUFA status were supplemented with EPA/DHA, suggesting that the coadministration of EPA/DHA together with the currently used TB antibiotics has no observable adverse effects. Abnormal bone remodeling destroys the microstructure of subchondral bone which results in articular cartilage degeneration. It was investigated that DHA was able to protect articular cartilage by preserving the microstructure of subchondral bone. Activation of Wnt/β catenin pathway promotes differentiation into osteoclasts, promoting osteoblast proliferation.
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