Applications of Nanomaterials for Activation and Suppression of Immune Responses

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Author(s): Akhilesh Kumar Shakya (Texas Tech University, USA)and Kutty Selva Nandakumar (Karolinksa Institute, Sweden & University of Arkansas, USA)
Copyright: 2015
Pages: 16
Source title: Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering
Source Author(s)/Editor(s): Shivani Soni (Alabama State University, USA), Amandeep Salhotra (City of Hope National Medical Center, USA)and Mrutyunjay Suar (KIIT University, India)
DOI: 10.4018/978-1-4666-6363-3.ch011

Keywords: Computer Science & IT / Engineering Science / Engineering Science Reference / Nanotechnology

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Abstract

Evaluation of immuno-modulating properties of nanomaterials is important to develop new potential therapeutics for inflammatory diseases and cancer. Activation and suppressive effects of nanomaterials on immune responses occur through various interactions with different host proteins. They can also be engineered as carriers and/or adjuvants for different proteins or antigens. Particles, emulsions, and tubes/rods are the major formats of nanomaterials currently used in biomedical applications. Sometimes, nanomaterials induce side effects like undesired immunosuppression and toxicities, which are major concerns at present in designing optimal nanotherapeutics. This chapter summarizes different types of nanomaterials and their effect on immune responses.

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