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An Alternate Strategy for the Regulation of Inflammatory and Autoimmune Disorders: The Role of Gut Microbiota and Dietary Metabolites
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Author(s): Sangeeta Chhotaray (Centurion University of Technology and Management, India)and Soumya Jal (Centurion University of Technology and Management, India)
Copyright: 2024
Pages: 19
Source title:
Nutrition Controversies and Advances in Autoimmune Disease
Source Author(s)/Editor(s): Srikanta Patnaik (SOA University, India & Interscience Institute of Management and Technology, India), Ahmed M. Hamad (Benha University, Egypt), Debjyoti Paul (Amity University, Kolkata, India), Pushan Kumar Dutta (Amity University, Kolkata, India)and Muhammad Shafiq (Guangzhou University, China & Shenyang Normal University, China)
DOI: 10.4018/979-8-3693-5528-2.ch013
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Abstract
Dysregulated immune responses against self-antigens cause tissue damage and chronic inflammation, which in turn cause autoimmune disorders. Dietary variables and nutritional imbalances contribute to the development and progression of autoimmune pathogenesis, while genetic predisposition is also involved. The gut microbiota, a community of microorganisms in the gastrointestinal tract, is crucial for human health and disease. The relationship between dietary nutrients and the gut microbiota is complex, with nutrients influencing microbial composition and function, while the gut microbiota influences nutrient metabolism and absorption. Key nutrients, such as fibers, proteins, fats, vitamins, and minerals, affect gut microbial communities, while the gut microbiota contributes to the bioavailability of essential nutrients and the synthesis of bioactive compounds. Dysregulation of this symbiotic relationship, known as dysbiosis, has been linked to various diseases. Understanding this complex interplay offers potential therapeutic interventions for promoting gut health, modulating immune function, and managing disease states. Future research should focus on understanding the mechanisms of nutrient-microbiota interactions, exploring personalized dietary approaches, and harnessing nutritional interventions for optimizing human health and well-being. Therefore, nutrition plays an important part in the development of autoimmune illnesses; this chapter focuses on the ways nutrition affects inflammation, autoimmunity, and immune function. Diet has emerged as a major lifestyle component in the epidemic of inflammatory diseases and autoimmune disorders, which is affecting people in both industrialised and developing nations. Also, the current “Western diet” has altered in recent years, adding more calories and changing the proportions of various food groups, such as reducing fibre and increasing fat and carbohydrate quality. Because alterations in the makeup of the gut microbiota are linked to numerous inflammatory disorders, the fact that diet modifies the microbial ecology of the large intestine may have significant implications for human health.
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