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The Aging Brain: From Physiology to Neurodegeneration
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Author(s): Rashi Rajput (Jaypee Institute of Information Technology, India), Ramneek Kaur (Jaypee Institute of Information Technology, India), Rishika Chadha (Jaypee Institute of Information Technology, India), Shalini Mani (Jaypee Institute of Information Technology, India), Rachana R. (Jaypee Institute of Information Technology, India), Harleen Kaur (Amity Institute of Biotechnology, India)and Manisha Singh (Jaypee Institute of Information Technology, India)
Copyright: 2019
Pages: 23
Source title:
Handbook of Research on Critical Examinations of Neurodegenerative Disorders
Source Author(s)/Editor(s): Md. Sahab Uddin (Southeast University, Bangladesh)and Md. Shah Amran (University of Dhaka, Bangladesh)
DOI: 10.4018/978-1-5225-5282-6.ch001
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Abstract
Neurodegeneration is the progressive and gradual dysfunction and loss of axons in the central nervous system. It is the main pathological characteristic of chronic and acute neurodegenerative conditions like Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The usual aspects of pathogenesis of disease can be abridged with regards to the downstream implications of uncontrollable protein oligomerization and aggregation from postmitotic cells. The brain structure constantly changes in normal aging without any dysfunction accompanying the structural changes in brain. The decline in cognitive capabilities, for example, processing speed, memory, and functions related to decision making are the sign of healthy aging. The reduction in brain volume in healthy aging is possibly related to neuronal loss at some marginal extent. The following chapter discusses the structural and functional alterations in the brain in ageing and neurodegeneration.
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