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Oxidative Stress and Neurodegeneration
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Author(s): Newman Osafo (Kwame Nkrumah University of Science and Technology, Ghana), David Darko Obiri (Kwame Nkrumah University of Science and Technology, Ghana), Kwabena Owusu Danquah (Kwame Nkrumah University of Science and Technology, Ghana), Oduro Kofi Yeboah (Kwame Nkrumah University of Science and Technology, Ghana), Aaron Opoku Antwi (Kwame Nkrumah University of Science and Technology, Ghana)and Mahmood Brobbey Oppong (University of Ghana, Ghana)
Copyright: 2019
Pages: 24
Source title:
Handbook of Research on Critical Examinations of Neurodegenerative Disorders
Source Author(s)/Editor(s): Md. Sahab Uddin (Southeast University, Bangladesh)and Md. Shah Amran (University of Dhaka, Bangladesh)
DOI: 10.4018/978-1-5225-5282-6.ch002
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Abstract
Neurons are the building units of the nervous system and are therefore critical units for the health of the brain and the spinal cord. This is necessitated by their inability to be either replaced or reproduced once lost. Their losses are implicated in a number of conditions which have been elaborated in this chapter. Oxidative stress has been strongly implicated in neurodegeneration through blockade of neuroprotection by a number of mechanisms including inhibitory effect on insulin-like growth factor I (IGF-1) via stimulation of the transcription factor, Forkhead box O3 (FOXO3). This chapter elaborates on these two phenomena which cannot be decoupled.
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