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The Therapeutic Role of Secondary Metabolites in Neurodegenerative and Inflammatory Diseases, Mechanisms, and Potential Applications
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Author(s): Jawad Laadraoui (Faculty of Sciences, Aïn Chock, Hassan II University, Casablanca, Morocco), Hamid Kabdy (Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco), Sara Oufquir (Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco), Mehdi Aitlarradia (Ministry of Health and Social Protection, Beni Mellal, Morocco), Fatimzahra Agouram (Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco), Abdelfatah Ait Baba (Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco), Khadija Oubella (Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco)and Bilal El-Mansoury (Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Ireland)
Copyright: 2025
Pages: 64
Source title:
Secondary Metabolites and Their Applications in Various Diseases
Source Author(s)/Editor(s): Athanasios Alexiou (Novel Global Community Education Foundation, Australia), Saurabh Kumar Jha (Department of Zoology, Kalindi College, University of Delhi, India)and Roma Pandey (Department of Biotechnology, IILM University, Greater Noida, India)
DOI: 10.4018/979-8-3693-9112-9.ch005
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Abstract
Secondary metabolites, bioactive compounds from plants, fungi, and microorganisms, show significant therapeutic potential for neurodegenerative and inflammatory diseases. This chapter highlights their mechanisms of action, including antioxidant activity, modulation of inflammatory pathways, and neuroprotection, supported by preclinical and clinical evidence. Key classes like alkaloids, flavonoids, terpenoids, and polyphenols are explored for their neuroprotective and anti-inflammatory properties, alongside phytochemical sources that emphasize their drug discovery potential. However, challenges such as limited bioavailability, stability, and toxicity hinder their clinical application. Addressing these issues through novel strategies could unlock their full potential in modern medicine. This chapter bridges natural product chemistry and clinical applications, providing insights to inspire further research into secondary metabolites as essential tools for combating complex diseases.
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