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The Cancer Exposome: Gene-Environment Interactions (GxE) in Carcinogenesis
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Author(s): Divya A. P. (Sri Sathya Sai University for Human Excellence, Kalaburagi, India), Mahalakshmi K. M. (Sri Sathya Sai University for Human Excellence, Kalaburagi, India), Sai Priyanka J. (Sri Sathya Sai University for Human Excellence, Kalaburagi, India)and Ramya Raghavan (Sri Sathya Sai University for Human Excellence, Kalaburagi, India)
Copyright: 2026
Pages: 32
Source title:
Cancer Exposomics and Environmental Influences on Carcinogenesis
Source Author(s)/Editor(s): Ramya Raghavan (Sri Sathya Sai University for Human Excellence, India)
DOI: 10.4018/979-8-3373-2165-3.ch004
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Abstract
Gene-environment interactions play a crucial role in tumor initiation by influencing cellular and tissue plasticity. Environmental and internal factors influence carcinogenesis by acting on specific sensing genes and pathways, leading to epigenetic, genetic, and metabolic changes that shape the TME. Understanding the exposome can inform gene expression, epigenetic changes, and immune responses, particularly for the reproductive health and cancer prevention. The authors discuss the latest methodologies in exposome assessment, challenges in defining and measuring harmful environmental impacts. Exposome applications in public health policy face challenges and also opportunities in translating exposome research into actionable measures. Gene-environment interactions are shown by analyzing case studies, emerging debates in research, and clinical practice. This work highlights the transformative potential of exposome informed policies in addressing global health challenges and reducing health disparities.
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