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Terpenes and Lung Cancer
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Author(s): Vaibhav Rajoriya (Vedic Institute of Pharmaceutical Education and Research, Sagar, India), Vibha Rajoriya (Vedic Institute of Pharmaceutical Education and Research, Sagar, India), Ravikant Gupta (Oriental University, Indore, India), Sudha Gupta (Oriental University, Indore, India)and Sachin K. Jain (Oriental University, Indore, India)
Copyright: 2025
Pages: 20
Source title:
Analyzing Terpenes' Role in Cancer Treatment
Source Author(s)/Editor(s): Bhawna Chopra (Guru Gobind Singh College of Pharmacy, India), Ashwani Kumar Dhingra (Global Research Institute of Pharmacy, India), Priyanka Kriplani (Guru Gobind Singh College of Pharmacy, India)and Ritu Ojha (Cathay General Hospital, Taiwan)
DOI: 10.4018/979-8-3693-6972-2.ch004
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Abstract
Terpenoids, a broad category of secondary metabolites found in plants, have been recognized for their antioxidant, anti-inflammatory, and anticancer characteristics. These substances, which encompass monoterpenes to poly-terpenes, have been observed to impact various phases of tumor development, from the early onset and progression of tumorigenesis to the later stages of angiogenesis, invasion, and metastasis. With respect to lung cancer, a number of terpenoids have demonstrated potential effectiveness. Monoterpenes, for instance, have been associated with the prevention of cancers in the breast, liver, and lungs. Additionally, cannabinoids, a subset of terpenes, have exhibited anti-tumor effects specifically targeting lung cancer. While the anticancer properties of terpenoid are promising, there is a need for more comprehensive preclinical and translational research to fully understand their potential and to develop effective therapeutic strategies. A key area of focus in this research is understanding the complex interplay between apoptosis and autophagy, which is driven by the activation or silencing of specific proteins, in the context of terpenoid induced autophagy in cancer cells. In conclusion, terpenoids present a promising path for the development of new therapies in the management and treatment of lung cancer.
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