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Scaffold for Tissue Engineering Design Fabrication and Applications
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Author(s): Nida Iqbal (University of Engineering and Technology Lahore, Pakistan), Muhammad Asad Ullah (University of Engineering and Technology, Lahore, Pakistan), Muhammad Zaeem Khalid (University of Engineering and Technology, Lahore, Pakistan)and Syed Tasawar Hussain (University of Engineering and Technology, Lahore, Pakistan)
Copyright: 2025
Pages: 32
Source title:
Innovations and Applications of Advanced Biomaterials in Healthcare and Engineering
Source Author(s)/Editor(s): Safaa Najah Saud Al-Humairi (Management and Science University, Malaysia), Erkan Koç (Karabuk University, Turkey)and Amir Najah Saud Al-Humairi (Al-Mustaqabal University, Iraq)
DOI: 10.4018/979-8-3373-1305-4.ch010
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Abstract
Recently, Tissue engineering (TE) has been rapidly growing field in biomedical field, it provides the solutions to the problem such as immunological rejection and a shortage of available donors. TE scaffolds encourage cell adhesion, proliferation, and differentiation by simulating the extracellular matrix with three-dimensional matrices. Current, advancements in artificial intelligence (AI) and nanotechnology have improved the design, pore size, mechanical properties. However, scaffolds lack the ability of vascularization, immune compatibility, and scalability. In order to address this issue, scaffolds surface-functionalized with anti-inflammatory cytokines such as IL-10 that can increase the integration, less rejection, and long-term performance. Therefore, it is considered that the combination of nanotechnology and AI scaffold design will enhance bioactivity, mechanical strength, and cellular behavior modeling. Regenerative medicine is poised for a revolution due to significant advancements in scaffold-based TE.
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