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Reactive Oxygen Species in Neurodegenerative Disorders: Mechanisms and Therapeutics
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Author(s): Arushi Sharma (Shiva Institute of Pharmacy, India), Smriti Tiwari (Teerthanker Mahaveer University, India), Himanshu Sharma (Teerthanker Mahaveer University, India), Rashmi Pathak (Invertis University, India)and Farhan Khan (Fergana Medical Institute of Public Health, Kazakhstan)
Copyright: 2025
Pages: 30
Source title:
The Role of Reactive Oxygen Species in Human Health and Disease
Source Author(s)/Editor(s): Pranav Kumar Prabhakar (Department of Biotechnology, Nagaland University, India)
DOI: 10.4018/979-8-3693-7919-6.ch012
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Abstract
Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen. In the context of neurodegenerative disorders, ROS play a dual role while they are necessary for normal cellular function, their overproduction can lead to oxidative stress, damaging neurons and contributing to the pathogenesis of diseases such as Alzheimer's, Parkinson's, Huntington's, and Amyotrophic Lateral Sclerosis (ALS). This book chapter explores the mechanisms by which ROS contributes to neurodegeneration, including mitochondrial dysfunction, protein aggregation, and inflammation. Additionally, we discuss current and emerging therapeutic strategies aimed at modulating ROS levels and mitigating oxidative damage, such as antioxidants, gene therapy, and lifestyle interventions. Understanding the balance between ROS production and antioxidant defenses is crucial for developing effective treatments for neurodegenerative diseases.
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