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QSAR Studies on Bacterial Efflux Pump Inhibitors
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Author(s): Khac-Minh Thai (University of Medicine and Pharmacy at HCMC, Vietnam), Trong-Nhat Do (University of Medicine and Pharmacy at HCMC, Vietnam), Thuy-Viet-Phuong Nguyen (University of Medicine and Pharmacy at HCMC, Vietnam), Duc-Khanh-Tho. Nguyen (University of Medicine and Pharmacy at HCMC, Vietnam)and Thanh-Dao Tran (University of Medicine and Pharmacy at HCMC, Vietnam)
Copyright: 2017
Pages: 31
Source title:
Pharmaceutical Sciences: Breakthroughs in Research and Practice
Source Author(s)/Editor(s): Information Resources Management Association (USA)
DOI: 10.4018/978-1-5225-1762-7.ch035
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Abstract
Antimicrobial drug resistance occurs when bacteria undergo certain modifications to eliminate the effectiveness of drugs, chemicals, or other agents designed to cure infections. To date, the burden of resistance has remained one of the major clinical concerns as it renders prolonged and complicated treatments, thereby increasing the medical costs with lengthier hospital stays. Of complex causes for bacterial resistance, there has been increasing evidence that proved the significant role of efflux pumps in antibiotic resistance. Coadministration of Efflux Pump Inhibitors (EPIs) with antibiotics has been considered one of the promising ways not only to improve the efficacy but also to extend the clinical utility of existing antibiotics. This chapter begins with outlining current knowledge about bacterial efflux pumps and drug designs applied in identification of their modulating compounds. Following, the chapter addresses and provides a discussion on Quantitative Structure-Activity Relationship (QSAR) analyses in search of novel and potent efflux pump inhibitors.
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