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Protective Effects of Cannabis in Neuroinflammation-Mediated Alzheimer's Disease
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Author(s): Mohd Kashif (B.S. Abdur Rahman Crescent Institute of Science and Technology, India), Mohammad Waseem (University of Maryland, Eastern Shore, USA), Poornima D. Vijendra (Davangere University, India)and Ashok Kumar Pandurangan (B.S. Abdur Rahman Crescent Institute of Science and Technology, India)
Copyright: 2023
Pages: 28
Source title:
Medical Cannabis and the Effects of Cannabinoids on Fighting Cancer, Multiple Sclerosis, Epilepsy, Parkinson's, and Other Neurodegenerative Diseases
Source Author(s)/Editor(s): Rana R. Zeine (Kean University, USA)and Brian W. Teasdale (Kean University, USA)
DOI: 10.4018/978-1-6684-5652-1.ch002
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Abstract
In recent years, Alzheimer's disease (AD) has been recognized as an age-related neurological disorder wherein neurons degenerate and exhibit abnormal structure and function. Aging is the primary factor in the progression of AD from mild to severe cognitive impairment. No effective targeted therapies are presently available, and treatment is limited to symptomatic management. The neuropathologic hallmarks of the disease include the accumulation of amyloid-beta (Aβ) plaques in brain tissues and the aggregation of hyperphosphorylated-tau proteins (tangles) within neurons. Associated hyperactivation of neuroinflammation results in release of inflammatory molecules from neurons, microglia, and astrocytes, which have been linked with neuronal loss and the worsening neurodegeneration. The anti-inflammatory and neuroprotective properties of cannabis-based medicines may offer benefits in delaying the progression of neurodegenerative diseases including AD. This chapter explores the role of cannabinoids in countering neuroinflammation-mediated AD pathology.
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